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AHCC® Shown to Inhibit Liver Fibrosis Progression in New Research 

Amino Up Co., Ltd. has conducted a joint study with Osaka Metropolitan University to investigate the effects of AHCC® on liver fibrosis progression. The research, published in the American Journal of Physiology-Gastrointestinal and Liver Physiology, suggests that AHCC® can inhibit the activation of hepatic stellate cells and thereby suppress liver fibrosis. 

The research team found that AHCC® effectively inhibited the activation of hepatic stellate cells, which play a crucial role in liver fibrosis. Furthermore, the expression of markers specific to activated hepatic stellate cells decreased, while the expression of cytoglobin, an anti-fibrotic protein, increased. By utilizing human hepatic stellate cells, we were able to elucidate the mechanisms underlying the inhibitory effects of AHCC® on liver fibrosis progression.  

[Published Information]  

Journal: American Journal of Physiology-Gastrointestinal and Liver Physiology 
Title: AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway 
Authors: Hayato Urushima*, Tsutomu Matsubara, Gu Qiongya, Atsuko Daikoku, Misako Takayama, Chiho Kadono, Hikaru Nakai, Yukinobu Ikeya, Hideto Yuasa, and Kazuo Ikeda 

URL: https://doi.org/10.1152/ajpgi.00134.2024