Amino Up Co., Ltd. has conducted a joint study with Osaka Metropolitan University to investigate the effects of AHCC® on liver fibrosis progression. The research, published in the American Journal of Physiology-Gastrointestinal and Liver Physiology, suggests that AHCC® can inhibit the activation of hepatic stellate cells and thereby suppress liver fibrosis.
The research team found that AHCC® effectively inhibited the activation of hepatic stellate cells, which play a crucial role in liver fibrosis. Furthermore, the expression of markers specific to activated hepatic stellate cells decreased, while the expression of cytoglobin, an anti-fibrotic protein, increased. By utilizing human hepatic stellate cells, we were able to elucidate the mechanisms underlying the inhibitory effects of AHCC® on liver fibrosis progression.
[Published Information]
Journal: American Journal of Physiology-Gastrointestinal and Liver Physiology
Title: AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK/JNK pathway and collagen production via TLR4-NF-κβ pathway
Authors: Hayato Urushima*, Tsutomu Matsubara, Gu Qiongya, Atsuko Daikoku, Misako Takayama, Chiho Kadono, Hikaru Nakai, Yukinobu Ikeya, Hideto Yuasa, and Kazuo Ikeda