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Oligonol® Research Presentations


Oligonol® Conference Presentation List

Nov.ISNFF 2013 Annual Conference & Exhibition
「The combinational use of Oligonol and Meratrim contributes to the body weight management in mice」
Takahiro Maeda, Hiroshi Nishioka (Amino Up Chemical Co., Ltd.) et al.
May.14th Clinical Applications for Age Management Medicine
“Nutritional Management of Diseases of Overt Inflammation: Impact on Cancer and Diabetes”
Okezie I. Aruoma (American University of Health Sciences, USA)
Apr.Experimental Biology 2013
“Effect of oligomerized polyphenol supplementation on lipid metabolism during exercise in healthy men.”
Satoshi Fujita (Ritsumeikan University) et al.
Mar.86th Annual Meeting of The Japanese Pharmacological Society
“Protective effects and molecular mechanisms of oligonol in UV-irradiated NIH3T3 cells”
Xiaohong Zhang (Amino Up Chemical Co., Ltd.) et al.

“Oligonol inhibited the NADPH oxidase activity and preserved the insulin signal in endothelial cells under diabetic consitions”
Hiroki Yokoo (University of Toyama)
Mar.NAPA 2012
“Chemopreventive Effects of Oligonol on Dextran Sulfate Sodium-induced Mouse Colitis and Underlying Biochemical Mechanisms”
Hye-Won Yum, Young-Joon Surh (Seoul National University, South Korea), et al.
Jan.RedCat meeting 2012
“Chemopreventive Effects of Oligonol on Dextran Sulfate Sodium-induced Mouse Colitis and Underlying Biochemical Mechanisms”
Hye-Won Yum, Young-Joon Surh (Seoul National University, South Korea), et al
Nov.2011 ISNFF Conference and Exhibition
“Promotion of healthcare by clinical trial system for foods and establishment of international food network”
Jun Nishihira (Hokkaido Information University)

“Effect of Oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on increased vasodilatory effect in cardiovascular tissues”
Manashi Bagchi, et al. (NutriToday, LLC, USA)
Oct.KSABC (The Korean Society for Applied Biological Chemistry)
“Oligonol Improves the Abilities of Memory and Cognition under Aβ25-35-induced Alzheimer’s Model”
Takoko Yokozawa (Toyama University, Eun Ju Cho (Pusan National University)
Sep.33rd ESPEN (European Society for Clinical Nutrition and Metabolism)
“Flavanol-rich Lychee Fruit Extract Suppresses Expression of Genes Involved in Inflammation in Rat Hepatocytes”
Tadayoshi Okumura (Kansai Medical University

“Supplementation with Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Long-distance Runners”
Tadayoshi Okumura (Kansai Medical University), Tadao Isaka, Mikio Nishizawa (Ritsumeikan University) et al.
Jul.43rd Annual Scientific Meeting of the Japan Atherosclerosis Society
“Intake of lychee fruits polyphenol improved LDL oxidizability and endothelial function in healthy subjects”
Yoshimi Kishimoto, Kazuo Kondo (Ochanomizu University) et al.
Jul.XI Asian Congress of Nutrition 2011
Anti-obese Effects of Dietary Lychee Polyphenol or Oliognol in OLETF Rats.
Kyoichi Osada (Meiji University)
Feb.ASPEN 2011 (American Society for Parenteral and Enteral Nutrition)
“The Integrative Approach for Cancer Patients with Metabolic Symdrome”
Toshinori Ito (Osaka University)

“Clinical Intervention for Health Promotion through Evaluation of Functional Foods in Hokkaido”
Jun Nishihira (Hokkaido Information University)

DecPACIFICHEM 2010 (2010 International Chemical Congress of Pacific Basin Societies)
“Oligonol, a highly bioavailable Lychee-derived polyphenolic antioxidant, in preventing obesity and metabolic syndrome”
Manashi Bagchi, et al. (NutriToday LLC, USA)
Nov.SIO 2010 (7th Annual International Conference of the Society for Integrative Oncology)
“Integrated and individualized lifestyle intervention for the patients with cancer and obesity”
Maeda K., Toshinori Ito (Osaka University)
Oct.2010 ISNFF Conference and Exhibition
“Facilitative Effects of Oligonol for Fatty Acid Oxidation in a High‐Fat Diet Murine Model”
Kohei Homma (Amino Up Chemical Co., Ltd.
Aug.25th ICP
“Bioactivity of an enhanced lychee fruit extract (Oligonol) on select markers of vascular health and oxidant defense in experimental animals and humans”
Sun Jung Yim, Robert M. Hackman, et al. (University of California, Davis, USA)
Jul.11th ICO (International Congress on Obesity)
“Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via activation of the ERK1/2 pathway”
Junetsu Ogasawara (Kyorin University)
Jun.59th Annual Congress of the Japan Society of Acupuncture and Moxibustion
“Botanical/herbal products, research and applications”
Gary E. Deng(Memorial Sloan-Kettering Cancer Center)
Apr.Experimental Biology meeting
“Effects of Oligonol Supplementation on the Appearance of Skin Photo-aging, Wrinkles, Hyperpigmentation and Lentigines”
Albert R. MacKenzie(American Board of Dermatology, USA)

“Cytoprotection of human endothelial cells from oxidative stress by polyphenols: the role of gene expression versus direct antioxidant effect”
Carl L. Keen, et al. (University of California, Davis, USA)
Mar.83rd Annual Meeting of Japanese Society for Bacteriology
“Therapeutic Effect of Oligonol on Murine Oral Candidiasis”
Shigeru Abe Mycol., (Teikyo University)
DecICPH 2009(4th International Conference on Polyphenols and Health)
“Metabolic Stem Cell (MSC) based treatment approach against lifestyle-related cancer patients”
Maeda, K (Osaka University)

“Acute Effects of a Flavanol-rich Lychee Fruit Extract (Oligonol) on Select Markers of Vascular Health and Oxidant Defense”
Robert M. Hackman(University of California, Davis, USA)

“Effect of lychee-derived low-molecular-weight polyphenol (Oligonol) on postprandial hyperglycemia”
Jun Nishihira (Hokkaido Information University)
Nov.The 2009 International Symposium on Nucleic Acid Chemistry
“Natural Antisense Trnascripts Involved in the Regulation of Cytokine Gene Expression by the Oligomerized Polyphenol Oligonol”
Mikio Nishizawa, Tadayoshi Okumura (Ritsumeikan University) et al.
Nov.ISNFF 2009(International Society for Nutraceuticals & Functional Foods)
“Lychee Oligonol as an Anti-aging and Innovative Nutritional Substance”
Anil Kulkarni(The University of Texas, USA)
Sep.31th ESPEN (European Society for Clinical Nutrition and Metabolism)
“Involvement of the Functional Food Oligonol in Hepatoprotection by Reduction of Nitric Oxide”
Mikio Nishizawa (Ritsumeikan University)
Jul.Chemoprevention and Translation Research
“Oligonol, a Low Molecular Weight Polyphenol Formulation, Inhibits UVB-Induced Lipid Peroxidation and COX-2 Expression, and Induces NQO1 in Hairless Mouse Skin”
Joydeb Kumar Kundu, Young-Joon Surh, et al.(Seoul National University, Korea)
Apr.3rd International Symposium on Nutrition, Oxygen Biology & Medicine
“New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue”
Hideaki Ohno (Kyorin University) et al.
Mar.82nd Meeting of the Japanese Pharmacological Society
“Oligonol preconditioning induces neuroprotection via upregulation of EAAT3 activity in LPS stimulated C6 cells”
Xiaohong Zhang (Amino Up Chemical Co., Ltd)
Feb.ASPEN (American Society of Parenteral and Enteral Nutrition)
“Dietary Nucleotides: Present Status and Future Directions”
Anil D. Kulkarni (University of Texas, Medical School, USA)

「Dietary Substrates: Fruit and Plant」
Toshinori Ito (Osaka University)

“Alleviating Function of Active Hexose Correlated Compound (AHCC), a health food component, for Side Effect in Chemotherapy Patients”
Hiroaki Yanagimoto (Kansai Medical University)
Nov.4th International Niigata Symposium on Diet and Health
“Oligonol normalizes insulin signaling inhibited by high level Glucose in human endothelial cells evidence for a role of oligonol in oxidative stress-mediated insulin resistance”
Xiaohong Zhang, Hiroshi Nishioka, Hajime Fujii (Amino Up Chemical Co., Ltd.)
“Amelioration of Abdominal Obesity by Low Molecular Weight Polyphenol (Oligonol) from Lychee”
Jun Nishihira, et al.(Hokkaido Information University, Japan)
“Absorption of a Lychee Fruit Extract Rich in Flavonoids (Oligonol) and Effects on Membrane Stability and Oxidant Defense in Animals and Humans”
Robert M. Hackman, Swati Kalgaonkar, Heidrun B. Gross, Carl L. Keen, Hajime Fujii, and Michael A. Dubick
May.ECO 2008
“Amelioration of abdominal obesity by low molecular weight polyphenol (Oligonol) from lychee”
Jun Nishihira1, Hiroki Sato1, Hideaki Murakami1, Kentaro Kitadate 2, Koji Wakame 2
1) Hokkaido Information University 2) Amino Up Chemical Co., Ltd.
“Oligonol Inhibits UVB- and/or Phorbol Ester-induced Expression of COX-2, Activation of Nuclear Factor-kB, AP-1 and C/EBP, and Chemically Induced Papillomagenesis in Mouse Skin In Vivo”
Joydeb Kumar Kundu and Young-Joon Surh (National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, Seoul National University, Seoul 151-742, Korea)
“Chemopreventive and Chemoprotective Effects of Oligonol, an Oligomeric Polyphenol Formulation, in Mouse Skin In Vivo”
Joydeb Kumar Kundu (College of Pharmacy, Seoul National University, Seoul, Korea)
Nov.ifia/HFE KYOTO2007
RM Hackman(UC Davis)
Sep.Clinical Nutrition Supplements
“Involvement of AHCC in expression of inducible nitric oxide synthase gene and relating genes”
M.Nishizawa (Ritsumeikan University)
“New lychee-derived polyphenol Oligonol converted into a low-molecular form reduces oxidative stress in adipocytes”
Sakurai Takuya(Department of Molecular Predictive Medicine and Sport Science, Kyorin University, Shool of Medicine)
“Novel Polyphenol Derivative”Cysteinyl-Oligo-Proanthocyanidin (Oligonol-CS)” is Effective against Skin Aging”
A.IDDAMALGODA etc(Ichimaru Pharcos Co., LTD)
Jun.20th Congress of the International Union of Biochemistry and Molecular Biology (79th Meeting of The Japanese Biochemical Society)
“Examination of the anti-oxidative effect of new polyphenol Oligonol in adipocytes”
Tatsuya Sakurai (Kyorin University)
Apr.97th American Association for Cancer Research Annual Meetings(Washington,DC,USA)
“Formulated oligomeric polyohenols (oligonol) from grape seeds inhibit phorbol ester-inducedtumor promotion and COX-2 expression in mouse skin: nuclear factor-kB and CCAAT/enhancer binding protein as potential targets”
J-K.Kundu, Y-K.Shin and Y-J.Surh(Seoul National Univ.)
Nov.Meeting of the Phytochemical Society of Europe(Portugal)
“Grape Flavonoids: Ancient Wisdom and Modern Advances”
Robert M. Hackman, Ph.D., et al(Department of Nutrition University of California) Buxiang Sun (Amino Up Chemical Co., Ltd)
Nov.The 2nd APOCP General Assembly Conference(SOUL)
“Oligonol Inhibits Phorbol Ester-Induced COX-2 Expression And Tumor Promotion In Mouse Skin”
J K Kundu(College of Pharmacy, Seoul National University, Seoul, Korea)
May.ISCaP Symposium(in Kyoto)
“Oligonol Inhibits Phorbol Ester-induced Tumor Promotion, Expression of COX-2 and Activation Of Nuclear Factor-κB in Mouse Skin”
Young-Joon Surh(Seoul National University)
May.Coorganized by College of Pharmacy, Seoul National University and NRL Free Radical Research
Buxiang Sun and Lan Yuan