| 1977 | Establishment of Institute of Hokkaido Fodder (private company) |
| 1981 | Development of plant growth regulator ‘Amino Up’ |
| 1984 | Company incorporated as Amino Up Chemical |
| 1989 | Development and debut of cultured Lentinula Edodes Extract ‘AHCC®’ |
| 1996 | Company relocated to new office, laboratory, and factory at Sapporo High-Tech Hill, Shin-ei |
| 1998 | Development and debut of buckwheat derived antioxidant ‘PMP’ *No longer sold |
| 2000 | Development and debut of high genistein content soybean extract ‘GCP®’ |
| 2002 | ISO 9002, HACCP-9000 certification |
| 2003 | ISO 9001 certification |
| 2005 | Grant program for complementary and alternative medicine at Osaka University Graduate School of Medicine established. Distinguished Lecture Series grant program established at the Department of Nutrition, UC Davis. |
| 2006 | Development and debut of lychee-derived low molecular weight polyphenol ‘Oligonol®’ |
| 2007 | ISO 22000, GMP certification |
| 2011 | Completion of new AHCC® manufacturing facility and Eco-House building |
| 2012 | Development and debut of asparagus extract, ‘ETAS®’ |
| 2014 | Oligonol® obtains FDA-notified GRAS status |
| 2015 | ETAS® obtains self-affirmed GRAS status. Oligonol® approved as ‘food with functional claims’ by Consumer Affairs Agency, Japan. |
| 2018 | Change of the company name to "Amino Up" |
